Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 354 |
| PDBID: | 2VDQ |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.59 |
| Reference: | 10.1083/jcb.200801146 |
| Antibody | |
| Antibody: | 10E5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Integrin AlphaIIb |
| Antigen mutation: | No |
| Durg Target: | P08514 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2VDQ_H|Chain D[auth H]|MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN|MUS MUSCULUS (10090) EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYVHWVKQRPEQGLEWIGRIDPANGYTKYDPKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCVRPLYDYYAMDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGP |
Light Chain: L
Mutation: NULL
| >2VDQ_L|Chain E[auth L]|MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN|MUS MUSCULUS (10090) DILMTQSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFMGLIYYGTNLVDGVPSRFSGSGSGADYSLTISSLDSEDFADYYCVQYAQLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >2VDQ_A|Chain A|INTEGRIN ALPHA-IIB|HOMO SAPIENS (9606) LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 THR32 TYR33 ARG50 ASN55 TYR57 LYS59 ARG98 PRO99 LEU100 TYR101 ASP102 TYR103 TYR104 L: SER30 ASN32 TYR49 TYR50 ASN53 LEU54 ASP56 TYR91 ALA92 GLN93 LEU94 A: ARG77 ASN78 VAL79 GLY80 SER81 GLN82 LEU84 GLU117 ARG147 GLY148 ASN149 THR150 ILE154 ASN158 SER205 SER206 ARG208 PRO209 GLY210 ILE211 LEU213 TRP214 HIS215 SER217 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
