Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3480 |
| PDBID: | 7CR5 |
| Chains: | HL_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.08 |
| Reference: | 10.1038/s41467-021-23036-9 |
| Antibody | |
| Antibody: | nCoV396 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 nucleocapsid protein NTD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7CR5_H|Chain B[auth H]|monoclonal antibody chain H|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYIMHWVRQAPGKGLEWVAVISYDGSNEAYADSVKGRFTISRDNSKNTLYLQMSSLRAEDTGVYYCARETGDYSSSWYDSWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >7CR5_L|Chain C[auth L]|monoclonal antibody chain L|Homo sapiens (9606) QLVLTQSPSASASLGASVKLTCTLSSGHSNYAIAWHQQQPEKGPRYLMKVNSDGSHTKGDGIPDRFSGSSSGAERYLTISSLQSEDEADYYCQTWGTGIQVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >7CR5_A|Chain A|Nucleoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) RPQGLPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ILE33 HIS35 TRP47 VAL50 SER52 TYR53 ASN57 GLU58 ALA59 GLU99 THR100 GLY101 ASP102 TYR103 SER104 SER105 SER106 L: GLN1 VAL3 SER25 SER26 GLY27 HIS28 SER29 ASN30 TYR31 ALA32 TRP95 GLY96 THR97 GLY98 ILE99 GLN100 A: ALA55 LEU56 THR57 HIS59 GLY60 LEU64 LYS65 PHE66 PRO67 GLN70 ILE74 VAL158 LEU159 GLN160 LEU161 PRO162 GLN163 GLY164 THR165 THR166 LEU167 PRO168 LYS169 GLY170 PHE171 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
