Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3466 |
| PDBID: | 7CJ2 |
| Chains: | KL_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 7CJ2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Chitinase 3-like 1 (YKL-40), isoform CRA_a |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >7CJ2_K|Chain A[auth C], E[auth K]|Fab(Heavy chain)|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVSGISGSGGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGVGTFDVWGQGTLVTVSSASTAKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT |
Light Chain: L
Mutation: NULL
| >7CJ2_L|Chain B[auth D], F[auth L]|Fab(Light chain)|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQTISSWLNWYQQKPGKAPKLLIYAASRLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGQGTKVEIKASTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >7CJ2_B|Chain C[auth A], D[auth B]|Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a|Homo sapiens (9606) YKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: THR28 SER30 ASN31 TYR32 ALA33 MET34 SER35 TRP47 GLY50 ILE51 SER52 GLY53 SER54 GLY55 GLY56 THR57 TYR59 GLY98 VAL99 GLY100 THR101 PHE102 L: THR28 SER30 SER31 TRP32 TYR49 ALA50 ARG53 SER67 SER91 TYR92 THR94 LEU96 B: GLN12 TYR13 ARG14 GLU15 GLY16 SER19 PHE21 ASP23 ASN39 SER41 ASN42 HIS44 ASP46 THR47 TRP48 TRP50 ASN51 VAL53 THR54 LEU55 GLY57 MET58 PRO104 PHE105 THR108 HIS109 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
