Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3434 |
| PDBID: | 7C81 |
| Chains: | HL_A |
| Organism: | Echovirus E30, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.1038/s41467-020-18250-w |
| Antibody | |
| Antibody: | 6C5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Echovirus 30 (E30) VP1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7C81_H|Chain F[auth H]|Heavy chain|Mus musculus (10090) QVQLQQSGSELVRPGASVKLSCRASGYTFTTYWMHWVKQRPGQGLEWIGNIYPHSGNTNYDERFKSKATLTVDTSSSTAYMQLSSLTSEDSAVYYCTRDLRGFAYWGQGTTVTVSSPKTTPPSVYPLAPAAASTAASMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >7C81_L|Chain E[auth L]|Light chain|Mus musculus (10090) DIELTQSPAIMSASPGEKVTMTCSASSSLRYMHWYQQKSGTSPKRWIYDTYNLASGVPVRFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPPTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >7C81_A|Chain A|VP1|Echovirus E30 (41846) NDPESALNRAVGRVADTVASGPVNTEQIPALTAVETGHTSQVVPSDTMQTRHVINYHTRSESSIENFMGRAACVYIAQYATEKVNDELDRYTNWEITTRQVAQLRRKLEMFTYMRFDLEITFVITSSQRTSTTYASDSPPLTHQVMYVPPGGPIPKSYEDFAWQTSTNPSVFWTEGNAPPRMSIPFMSVGNAYCNFYDGWSHFSQSGVYGYTTLNNMGHLYFRHVNKSTAYPVNSVARVYFKPKHVKAWVPRAPRLCPYLKARNVNFNVQGVTESRNKITLDRSTHNPLANT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ARG30 TYR31 HIS33 TYR48 TYR51 ASN52 LEU53 TRP90 SER91 SER92 H: THR28 THR31 TYR32 TRP33 TYR52 HIS54 SER55 ASN57 ASP99 LEU100 ARG101 A: TYR75 GLU82 LYS83 VAL84 ASN85 ASP86 GLU87 ASP89 ARG90 TYR91 THR92 ASN93 GLU95 ILE154 LYS156 SER157 TYR158 GLU159 HIS219 SER228 THR229 ALA230 TYR231 PRO232 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
