Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3417 |
| PDBID: | 7BSC |
| Chains: | HL_A |
| Organism: | dengue virus type 2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.31 |
| Reference: | 10.1126/science.abb9425 |
| Antibody | |
| Antibody: | 1G5.3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | DENV2 non-structural protein 1 |
| Antigen mutation: | No |
| Durg Target: | P27914; P12823; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7BSC_H|Chain B[auth H]|1G5.3 Fab Heavy Chain|Homo sapiens (9606) EVKLQESGPGLVRPSQSLSLTCSVTGYSITSGYYWNWIRQFPGNKLEWMGYISYDGRSNYNPSLKNRISITRDTSKNQFFLKLNFVTTEDTATYYCASFYYYTSRPLVYWGQGTLLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >7BSC_L|Chain C[auth L]|1G5.3 Fab Light Chain|Homo sapiens (9606) EIVLTQSPASLAVSLGQRATISCRASESVEYSGTSLMHWYQQKPGQPPKLLIYAASNVESGVPARFSGSGSGTDFSLNIHPVEEDDIAMYFCQQSRKVPYTFGGGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7BSC_A|Chain A|Non-structural protein 1|Dengue virus 2 (11060) KEKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMIIPKNFAGPVSQHNYRPGYHTQTAGPWHLGSLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: GLU20 VAL21 GLY45 TYR46 SER47 SER50 TYR52 TYR73 TYR119 TYR121 THR122 SER123 PRO125 VAL127 TYR128 L: LEU69 TYR72 VAL77 GLU78 SER79 GLY80 VAL81 A: GLU281 GLY282 ARG299 THR300 THR301 ALA303 SER304 GLY305 LYS306 LEU307 THR309 GLU326 ASP327 GLY328 GLU343 ASN344 LEU345 ASN347 SER348 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
