Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3416 |
| PDBID: | 7BQ5 |
| Chains: | CD_B |
| Organism: | Zika virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.99 |
| Reference: | 10.1038/s41590-021-00966-6 |
| Antibody | |
| Antibody: | Z6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >7BQ5_C|Chain B[auth C], E[auth H]|Z6 heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLICTVSGGSISTRDYYWGWIRQTPGKGLEWIGSIYYSGGTYYSPSLKSRVTISVDTSKNQFSLKLRSVTAADTAVYYCARQWGNYFDHWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: D
Mutation: NULL
| >7BQ5_D|Chain C[auth D], F[auth L]|Z6 Light Chain|Homo sapiens (9606) DIVLTQSPSFLSASVGDRVTITCRASQGIDTYLAWYQQKPGKAPKLLIYGASTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQLNNYHFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: B
Mutation: NULL
| >7BQ5_B|Chain A, D[auth B]|envelope protein|Zika virus (64320) IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTIGKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: TYR35 TRP49 SER52 TYR54 TYR60 GLN100 GLY102 ASN103 D: GLY28 ILE29 ASP30 TYR32 LEU91 ASN92 ASN93 TYR94 PHE96 B: PRO75 THR76 GLN77 TRP101 GLY102 GLY104 CYS105 GLY106 LEU107 PHE108 GLY109 LYS110 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
