Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3413 |
| PDBID: | 7BPK |
| Chains: | HL_B |
| Organism: | Zika virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1038/s41590-021-00966-6 |
| Antibody | |
| Antibody: | Z3L1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7BPK_H|Chain C, E[auth H]|Z3L1 Heavy chain|Homo sapiens (9606) EVQLVESGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKSTLYLQMNNLRAEDTAVYYCARDHLGWSSIWSAPESFLDYWGQGTLVTVSS |
Light Chain: L
Mutation: NULL
| >7BPK_L|Chain D, F[auth L]|IG c307_light_IGLV1-51_IGLJ2|Homo sapiens (9606) QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDSNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSVWVFGGGTKLT |
Antigen
Chain: B
Mutation: NULL
| >7BPK_B|Chain A, B|Envelope protein|Zika virus (64320) MIRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVNRGWGTGCLEWGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTIGKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: GLU1 SER25 GLY26 THR28 SER31 TYR32 TYR53 ASP54 ARG98 HIS100 LEU101 GLY102 SER104 SER105 ILE106 TRP107 SER108 PRO110 GLU111 PHE113 L: SER26 SER27 ASN31 ASN32 TYR33 TYR50 ASP51 LYS54 SER94 SER95 B: VAL46 THR47 SER51 ASN52 GLU55 LYS128 GLU136 ARG138 MET140 ASP155 THR156 HIS158 GLU159 THR160 ALA165 LYS166 GLU168 THR170 ASN208 THR231 GLU276 MET277 ASP278 GLY279 ALA280 LYS281 ARG283 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
