Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 341 |
| PDBID: | 2R29 |
| Chains: | HL_A |
| Organism: | Dengue virus 2 Thailand/16681/84, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1038/nsmb.1382 |
| Antibody | |
| Antibody: | 1A1D-2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Envelope protein E of Dengue virus |
| Antigen mutation: | No |
| Durg Target: | P12823; P27914; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2R29_H|Chain B[auth H]|Heavy chain of Fab 1A1D-2|Mus musculus (10090) EVQLQQSGAELVKPGASVKLSCTASGFNIKDTYMHWVKQRPEQGLEWIGRIDPANGYSKYDPKFQGKATITADTSSNAAYLQLSSLTSEDTAVYFCARDYEGFAYWGQGTLVTVSSAKTTPPSVYPLAPGAAAATSSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQTITCNVAHPASSTKVDKKIEPR |
Light Chain: L
Mutation: NULL
| >2R29_L|Chain C[auth L]|Light chain of Fab 1A1D-2|Mus musculus (10090) DIVLTQSPASLAVSLGQRATISCRASESVVRYGNSFMHWYQQKPGQPPKLLIYRASSLESGIPTRFSGSGSRTDFTLTINPVEADDVATYYCQQTNVDPWAFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: A
Mutation: NULL
| >2R29_A|Chain A|Envelope protein E|Dengue virus 2 Thailand/16681/84 (31634) SYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: VAL2 GLY26 PHE27 LYS30 ASP31 THR32 TYR33 ASP52 ALA54 ASN55 ARG98 ASP99 TYR100 GLU101 ALA104 TYR105 L: TYR32 GLY33 ASN34 PHE36 TYR53 ARG54 SER57 LEU58 GLU59 SER60 A: LYS305 PHE306 LYS307 VAL308 VAL309 LYS310 GLU311 ILE312 ARG323 GLN325 GLU327 LYS361 ASP362 PRO364 GLY385 GLN386 LEU387 LYS388 LEU389 ASN390 TRP391 PHE392 LYS393 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
