Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 338 |
| PDBID: | 2QR0 |
| Chains: | XW_V |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1016/j.jmb.2007.08.005 |
| Antibody | |
| Antibody: | 2QR0 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Vascular endothelial growth factor A |
| Antigen mutation: | No |
| Durg Target: | P15692 |
Sequence information
Antibody
Heavy Chain: X
Mutation: NULL
| >2QR0_X|Chain B, F, H, L, N, R, T, X|Fab-Fragment Heavy Chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFNFSSSSIHWVRQAPGKGLEWVAYIYPSYSYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARYYGTGAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: W
Mutation: NULL
| >2QR0_W|Chain A, E, G, K, M, Q, S, W|Fab-Fragment Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYSYYYYPFTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: V
Mutation: NULL
| >2QR0_V|Chain C, D, I, J, O, P, U, V|Vascular endothelial growth factor A|Homo sapiens (9606) EVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| W: TYR49 TYR91 SER92 TYR93 PRO95 X: SER31 SER32 SER33 HIS35 TYR50 TYR54 TYR56 TYR95 TYR96 GLY97 THR98 GLY99 V: TYR45 LYS48 MET81 ARG82 ILE83 LYS84 PRO85 HIS86 GLN87 GLY88 GLN89 HIS90 ILE91 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
