Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3370 |
| PDBID: | 7AZB |
| Chains: | B_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.62 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 7AZB VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Discoidin domain-containing receptor 2 |
| Antigen mutation: | No |
| Durg Target: | Q16832 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >7AZB_B|Chain B|VHH|Homo sapiens (9606) MKYLLPTAAAGLLLLAAQPAMAEVQLQASGGGFVQPGGSLRLSCAASGSSSWLDGMGWFRQAPGKEREFVSAISGQDNYASYYADSVKGRFTISRDNSKNTVYLQMNSLRAEDTATYYCAPQRSIYQSHKPIYWGQGTQVTVSSAAAHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7AZB_A|Chain A|Discoidin domain-containing receptor 2|Homo sapiens (9606) ALANPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLY55 PHE59 PHE69 SER74 ALA80 SER81 TYR82 TYR83 ALA84 ASP85 LYS88 ALA120 PRO121 GLN122 ARG123 SER124 ILE125 TYR126 SER128 HIS129 ILE132 TRP134 A: TRP53 GLU55 SER56 THR57 ASP70 CYS74 ILE77 PRO78 ARG106 HIS107 GLY109 GLY110 HIS111 GLY112 ILE113 GLU114 PHE115 SER146 ASN147 PRO148 TYR149 ASP150 ASN176 CYS178 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
