Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3323 |
| PDBID: | 6ZLR |
| Chains: | BC_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.3389/fphar.2020.615211 |
| Antibody | |
| Antibody: | CR3022 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6ZLR_B|Chain B[auth BBB], E[auth FFF], H[auth HHH]|CR3022 FAB HEAVY CHAIN|Homo sapiens (9606) QMQLVQSGTEVKKPGESLKISCKGSGYGFITYWIGWVRQMPGKGLEWMGIIYPGDSETRYSPSFQGQVTISADKSINTAYLQWSSLKASDTAIYYCAGGSGISTPMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: C
Mutation: NULL
| >6ZLR_C|Chain C[auth CCC], F[auth GGG], I[auth LLL]|CR3022 FAB LIGHT CHAIN|Homo sapiens (9606) DIQLTQSPDSLAVSLGERATINCKSSQSVLYSSINKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: A
Mutation: NULL
| >6ZLR_A|Chain A[auth AAA], D[auth DDD], G[auth EEE]|Spike glycoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: TYR27 GLY28 ILE30 THR31 TYR32 TRP33 TYR52 GLY54 ASP55 GLU57 ARG59 SER100 GLY101 ILE102 SER103 THR104 PRO105 ASP107 C: TYR31 SER32 SER33 ILE34 ASN35 LYS36 TYR38 TYR55 TRP56 GLU61 A: TYR51 ASN52 SER53 ALA54 PHE56 SER57 THR58 PHE59 LYS60 CYS61 TYR62 GLY63 VAL64 SER65 PRO66 THR67 LYS68 LEU72 PHE74 ARG90 ALA93 GLN96 ASP110 PHE111 THR112 PHE197 GLU198 LEU199 HIS201 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
