Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3318 |
| PDBID: | 6ZH9 |
| Chains: | AB_C |
| Organism: | Homo sapiens, Severe acute respiratory syndrome coronavirus 2, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.31 |
| Reference: | 10.1038/s41594-020-0469-6 |
| Antibody | |
| Antibody: | CR3022 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6ZH9_A|Chain A[auth HHH]|CR3022 heavy|Homo sapiens (9606) TQMQLVQSGTEVKKPGESLKISCKGSGYGFITYWIGWVRQMPGKGLEWMGIIYPGDSETRYSPSFQGQVTISADKSINTAYLQWSSLKASDTAIYYCAGGSGISTPMDVWGQGTTVTVASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS |
Light Chain: B
Mutation: NULL
| >6ZH9_B|Chain B[auth LLL]|CR3022 Light chain|Homo sapiens (9606) DIQLTQSPDSLAVSLGERATINCKSSQSVLYSSINKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: C
Mutation: NULL
| >6ZH9_C|Chain C[auth EEE]|Spike glycoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) ITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLN2 TYR28 GLY29 ILE31 THR32 TYR33 TRP34 TYR53 GLY55 ASP56 GLU58 ARG60 LYS75 SER101 GLY102 ILE103 SER104 THR105 PRO106 ASP108 B: TYR31 SER32 SER33 ILE34 ASN35 LYS36 TYR38 TYR55 TRP56 GLU61 C: TYR38 ASN39 SER40 PHE43 SER44 THR45 PHE46 LYS47 CYS48 TYR49 GLY50 VAL51 SER52 PRO53 THR54 LYS55 LEU59 PHE61 ARG77 ASP97 PHE98 THR99 PHE184 GLU185 LEU186 HIS188 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
