Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3294 |
| PDBID: | 6Z2L |
| Chains: | CB_A |
| Organism: | Plasmodium falciparum 3D7, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1128/mBio.01566-20 |
| Antibody | |
| Antibody: | P3.2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum P113 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6Z2L_C|Chain C|FAb fragment - VH chain|Mus musculus (10090) MGWTYIILFLVAAVTGVHSQVQLQQPGAELVKPGASVRLSCKASGYTFTSYFMYWVRQRPGQGLQSIGGINPNNGGSNFNERFKTKATLTVDKSSSIAYLQLNSLTSEDSAVYYCTRRGLGYDYGGFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR |
Light Chain: B
Mutation: NULL
| >6Z2L_B|Chain B|FAb fragment - VL chain|Mus musculus (10090) LLLCFQGTRCDIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVSSRFSGSGSGTDYSLTIKNLEQEDIATYFCQQVNALPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >6Z2L_A|Chain A|Surface protein P113|Plasmodium falciparum 3D7 (36329) YVHNDVIKFGEENSLKCSQGNLYVLHCEVQCLNGNNEIIHKRCNDDIEKKCNGNNKCIYFFEYELRKKTQSFRNKNSIEISECVESEQNEVKTSTTCLLSNSFILDEAFIQYFFFIKNKNEEPVICKDGNINIKSALLHSPFCEIKLKDISEYIRKKCDNNKECLIDPLDVQKNLLNEEDPCYINNAYVSVNVVCNK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: TYR42 TYR59 TYR60 SER62 ARG63 LEU64 LEU104 C: TYR46 THR47 THR49 SER50 TYR51 PHE52 ASN71 ASN73 ASN74 ARG118 LEU120 GLY121 TYR122 ASP123 TYR124 A: VAL6 LYS8 GLU28 GLN30 ASN36 ILE38 HIS40 GLN88 GLU90 LYS92 PRO141 PHE142 CYS143 GLU144 ILE145 LEU147 LEU176 ASN177 GLU178 GLU179 ASP180 PRO181 CYS182 TYR183 ASN186 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
