Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3285 |
| PDBID: | 6YZ7 |
| Chains: | BC_A |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.30 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | CR3022 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 Spike glycoprotein RBD |
| Antigen mutation: | No |
| Durg Target: | P0DTC2; P0DTC2; |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6YZ7_B|Chain B[auth BBB], G[auth HHH]|Antibody Cr3022|Homo sapiens (9606) TQMQLVQSGTEVKKPGESLKISCKGSGYGFITYWIGWVRQMPGKGLEWMGIIYPGDSETRYSPSFQGQVTISADKSINTAYLQWSSLKASDTAIYYCAGGSGISTPMDVWGQGTTVTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >6YZ7_C|Chain C[auth CCC], H[auth LLL]|Antibody light chain|Homo sapiens (9606) DIQLTQSPDSLAVSLGERATINCKSSQSVLYSSINKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6YZ7_A|Chain A[auth AAA], E[auth EEE]|Spike glycoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) PNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLN2 TYR28 GLY29 ILE31 THR32 TYR33 TRP34 TYR53 GLY55 ASP56 GLU58 ARG60 LYS75 SER101 GLY102 ILE103 SER104 THR105 PRO106 ASP108 C: TYR31 SER32 SER33 ILE34 ASN35 LYS36 TYR38 TYR55 TRP56 GLU61 A: SER37 TYR40 ASN41 SER42 ALA43 PHE45 SER46 THR47 PHE48 LYS49 CYS50 TYR51 GLY52 VAL53 SER54 PRO55 THR56 LYS57 LEU61 PHE63 VAL78 ARG79 ALA82 GLN85 ASP98 ASP99 PHE100 THR101 PHE186 GLU187 LEU188 HIS190 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
