Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3283 |
| PDBID: | 6YYE |
| Chains: | D_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.36 |
| Reference: | 10.1016/j.str.2021.06.010 |
| Antibody | |
| Antibody: | anti-TREM2 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Triggering receptor expressed on myeloid cells 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >6YYE_D|Chain C, D|TREM2 Single chain variable 2|Homo sapiens (9606) SMEVQLLESGGGLVQPGGSLRLSCAASGFTFYSSYMGWVRQAPGKGLEWVSYISSSGSSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVGGYYSWGNGIDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYGVYYPFTFGQGTKLEIK |
Antigen
Chain: B
Mutation: NULL
| >6YYE_B|Chain A, B|Triggering receptor expressed on myeloid cells 2|Homo sapiens (9606) ETGHNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLAD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: TYR35 SER54 SER55 SER56 SER58 SER59 THR60 TYR61 TYR104 TYR105 SER106 TRP107 TYR171 GLY231 VAL232 TYR234 PHE236 B: ASN20 VAL23 GLN25 ALA28 ARG52 GLN53 LEU54 GLY55 GLU56 GLN101 PRO102 HIS103 ALA105 GLY106 LEU107 LEU125 VAL126 GLU127 VAL128 LEU129 ALA130 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
