Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3279 |
| PDBID: | 6YWD |
| Chains: | AB_C |
| Organism: | Homo sapiens, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/s41589-020-00699-x |
| Antibody | |
| Antibody: | Mota Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Motavizumab(Phase-III) |
| Antigen | |
| Antigen: | De novo designed protein 4H_01 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6YWD_A|Chain A|Antibody Mota, Heavy Chain|Homo sapiens (9606) MGCVAETGQVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: B
Mutation: NULL
| >6YWD_B|Chain B|Antibody Mota, Light Chain|Homo sapiens (9606) MGCVAETGDIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6YWD_C|Chain C|De novo designed protein 4H_01|synthetic construct (32630) MEVERELRNWLSEVLSKINDAPVTNDIKKAISNQVLKVAEQVWNGHSKEELQERVRKEVCSVCSNVPACWAICGGLLEVVKYQGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: ALA40 GLY41 TRP62 TRP63 ASP64 LYS66 HIS68 ILE110 PHE111 ASN112 PHE113 B: ARG36 GLY38 TYR39 HIS41 ASP57 GLY98 SER99 GLY100 TYR101 C: SER12 LEU15 SER16 ILE18 ASN19 ASP20 THR24 ASN25 ASP26 LYS28 LYS29 ALA30 SER32 ASN33 LEU36 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
