Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3276 |
| PDBID: | 6YU8 |
| Chains: | B_A |
| Organism: | Sudan virus - Boniface, Sudan,1976, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.84 |
| Reference: | 10.1093/nar/gkaa1276 |
| Antibody | |
| Antibody: | 6YU8 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RNA Methyltransferase of Sudan Ebola Virus |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6YU8_B|Chain B|VHH antiboby|Lama glama (9844) DVQLVESGGGSVQAGGSLRLSCAASGRTFSRPVMAWFRQAPGKEREFVVAITWSGIRTSYADSVKGRFTISVDNAKDTVYLQMNSLKPEDTAVYYCAAGALPRTAHYEYDYWGLGTQVTVSSHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >6YU8_A|Chain A|Methyltransferase domain of the L protein|Sudan virus - Boniface, Sudan,1976 (128948) MHHHHHHEDHNAKEFPSNPHRLVVPFFKLTKDGEYSIEPSPEESRSNIKGLLQHLRTMVDTTIYCRFTGIVSSMHYKLDEVLWEYNKFESAVTLAEGEGSGALLLIQKYGVKKLFLNTLATEHSIESEVISGYTTPRMLLPIMPKTHRGELEVILNNSASQITDITHRDWFSNQKNRIPNDADIITMDAETTENLDRSRLYEAVYTIICNHINPKTLKVVILKVFLSDLDGMCWINNYLAPMFGSGYLIKPITSSAKSSEWYLCLSNLLSTLRTTQHQTQANCLHVVQCALQQQVQRGSYWLHHLTKYTT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: ARG27 PHE29 SER30 PRO32 VAL33 PHE47 THR52 TRP53 SER54 GLY55 ILE56 ARG57 THR58 SER59 ASN74 ALA100 LEU101 PRO102 ARG103 THR104 A: ARG1904 ASP1905 PHE1907 SER1908 LYS1911 GLU1938 TYR1941 THR1942 ILE1944 CYS1945 ASN1946 HIS1947 ILE1948 PRO1950 ASN1973 TYR1974 PRO1977 MET1978 LEU2004 LEU2005 SER2006 THR2007 LEU2008 ARG2009 THR2010 THR2011 GLN2012 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
