Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3262 |
| PDBID: | 6YE3 |
| Chains: | DE_F |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.89 |
| Reference: | 10.1126/scitranslmed.abb9283 |
| Antibody | |
| Antibody: | UFKA-20 Full-length |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-2 |
| Antigen mutation: | No |
| Durg Target: | P60568 |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6YE3_D|Chain A, D, G|Chain: A,D,G|Homo sapiens (9606) EVMLVESGGGLVKPGGSLKLSCAASGFSFSNYAMSWVRQTPERRLEWVALISGGGSYSYYPDSLKGRFTISRDSARNSLYLQMSSLRSEDTAMYYCARHMGYNDYLAWFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGKT |
Light Chain: E
Mutation: NULL
| >6YE3_E|Chain B, E, H|Chain: B,E,H|Homo sapiens (9606) DIVMTQSPSSLAVSVGQKVTMSCKSSQSLLNSANQKNYLAWYQQKPGQSPKLLIYFASTRESGVPDRFIGSGSGTDFTLNISSVQAEDLADYFCQQYYSAPPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: F
Mutation: NULL
| >6YE3_F|Chain C, F, I|Interleukin-2|Homo sapiens (9606) MAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition D: SER28 SER30 ASN31 TYR32 TYR57 TYR59 MET100 GLY101 TYR102 ASN103 ASP104 TYR105 LEU106 E: ASN31 SER32 ALA33 ASN34 LYS36 TYR38 PHE56 TYR97 TYR98 SER99 ALA100 F: GLN52 GLU55 GLU56 LEU58 LYS59 GLU62 GLU63 LEU75 ARG76 ARG78 ASP79 LEU80 ILE81 SER82 ASN83 ASN85 VAL86 LEU89 GLU90 LYS92 THR96 THR97 PHE98 MET99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
