Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3259 |
| PDBID: | 6YAX |
| Chains: | AD_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 5C05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | CD32b |
| Antigen mutation: | No |
| Durg Target: | P31994; P31995; P12318; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6YAX_A|Chain A[auth HHH], E[auth III]|5C05 F(ab) heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARENFDAFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: D
Mutation: NULL
| >6YAX_D|Chain B[auth LLL], D[auth MMM]|5C05 F(ab) light chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYSNSQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLNGQVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >6YAX_C|Chain C[auth AAA], F[auth BBB]|Low affinity immunoglobulin gamma Fc region receptor II-c|Homo sapiens (9606) TPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR31 TYR32 GLY33 VAL50 SER52 TYR53 ASP54 SER56 ASN57 TYR59 GLU99 ASN100 PHE101 ASP102 D: GLY32 ASP34 TYR51 SER52 ASN53 SER54 GLN55 TRP93 C: GLN21 GLU22 SER88 GLU89 TRP90 TRP113 LYS114 LYS116 LYS120 ASN157 ILE158 GLY159 TYR160 THR161 LEU162 TYR163 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
