Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3233 |
| PDBID: | 6XSN |
| Chains: | HL_C |
| Organism: | Macaca mulatta |
| Method: | XRD |
| Resolution (Å): | 2.87 |
| Reference: | 10.1371/journal.ppat.1009543 |
| Antibody | |
| Antibody: | VD20.5A4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 clade C 16055 strain V1V2 1FD6 scaffold |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6XSN_H|Chain A[auth H]|VD20.5A4_heavy_chain|Macaca mulatta (9544) QVQLQESGPGLVKPSETLSLTCAVSGASISSNYWSWIRQPPGKGLEWIGRIYDPTDSTDYNPSLESRATISKDTSKNHFSLTLSSVTAADTAVYFCARGLWSGYFFWFDVWGPGVLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >6XSN_L|Chain B[auth L]|VD20.5A4_light_chain|Macaca mulatta (9544) DIQMTQSPSSLSASVGDSVTVTCRASQGIDKELSWYQQKPGKAPTLLIYAASSLQTGVSSRFSGSGSGTDYTLTISSLQPEDVATYYCLQDYATPYSFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6XSN_C|Chain C|16055_V1V2-1FD6|Macaca mulatta (9544) MTTFKLAACVTLECRQVNTTNATSSVNVTNGEEIKNCSFNATTEIRDKKQKVYALFYRLDIVPLEEERKGNSSKYRLINCQTTTTEAVDAATAAKVFKQYANDNGIDGEWTYDDATKTFTVTXGLEVLFQGPGHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR33 ARG50 PRO53 THR54 SER56 TRP97 GLY99 L: ASP30 GLU32 ASP91 TYR92 THR94 TYR96 C: GLN133 LYS155 ARG178 PRO183 LEU184 GLU185 GLY186 LYS190 ARG192 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
