Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3232 |
| PDBID: | 6XRT |
| Chains: | HL_F |
| Organism: | Human immunodeficiency virus 1, Macaca mulatta |
| Method: | EM |
| Resolution (Å): | 3.90 |
| Reference: | 10.1126/science.abd2638 |
| Antibody | |
| Antibody: | VRC01.23 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 DS-SOSIP.664 gp160 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6XRT_H|Chain G[auth H]|VRC01.23 Heavy Chain|Macaca mulatta (9544) QVQLRESGPGLVKPSETLVLTCAVSGGGDSFGFHYWNWIRQPPGKGLEWIGHIGGSSGSTDFNPSLKSRVTISMDSSRNQFSLRLKSVTAADTAVYFCARKGEDFYEDDYGQYFTAGWFFDLWGPGTPIIISS |
Light Chain: L
Mutation: NULL
| >6XRT_L|Chain H[auth L]|VRC01.23 Light Chain|Macaca mulatta (9544) QFVLTQPPSVSGAPGQTVTISCTGRSSNFGGHYVQWYQQLPGTAPRLVIFENDRRPSGVSDRFSGSQSGASASLTITGLQSEDEADYYCQCYDSSVLFGRGTRLT |
Antigen
Chain: F
Mutation: NULL
| >6XRT_F|Chain A[auth E], C[auth F], D[auth G]|Envelope glycoprotein gp160|Human immunodeficiency virus 1 (11676) AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP98 PHE99 L: TYR32 GLU50 ASP52 ARG53 ARG54 SER56 F: THR123 PRO124 VAL127 GLN130 ASN160 MET161 THR162 ARG166 ASP167 LYS168 LYS169 GLN170 LYS171 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
