Complex | |
AACDB_ID: | 3230 |
PDBID: | 6XQW |
Chains: | HL_E |
Organism: | Homo sapiens, Plasmodium falciparum |
Method: | XRD |
Resolution (Å): | 2.99 |
Reference: | 10.1084/jem.20200942 |
Antibody | |
Antibody: | MaliM03 Fab |
Antibody mutation: | No |
INN (Clinical Trial): | |
Antigen | |
Antigen: | Pfmsp1-19 |
Antigen mutation: | No |
Durg Target: |
Antibody
Heavy Chain: H
Mutation: NULL
>6XQW_H|Chain A[auth H]|MaliM03 Fab Heavy Chain|Homo sapiens (9606) QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWTWIRQPPGKGLEWIGEINNSGKTNYNPSLKSRVSISIDTSKNQFSLKVTSVTAADTAVYYCARGPQQHLEPPFDYWGHGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
>6XQW_L|Chain B[auth L]|MaliM03 Fab Light Chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCSGSNSNIATNYVCWYQQYPGTAPKPLIYRTDQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCATWDDSLSAWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: E
Mutation: NULL
>6XQW_E|Chain C[auth E]|Pfmsp1-19|Plasmodium falciparum (5833) NISQHQCVKKQCPQNSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADAKCTEEDSGSNGKKITCECTKPDSYPLFDGIFCSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
H: TYR33 GLU50 PRO96 GLN97 GLN98 HIS99 L: THR30 ASN31 TYR32 ARG50 THR51 ASP52 LYS66 TRP91 ASP93 TRP96 E: HIS5 GLN6 CYS7 VAL8 LYS9 LYS10 GLN11 CYS12 GLU24 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)