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Entry information

Complex
AACDB_ID: 3230
PDBID: 6XQW
Chains: HL_E
Organism: Homo sapiens, Plasmodium falciparum
Method: XRD
Resolution (Å): 2.99
Reference: 10.1084/jem.20200942
Antibody
Antibody: MaliM03 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Pfmsp1-19
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>6XQW_H|Chain A[auth H]|MaliM03 Fab Heavy Chain|Homo sapiens (9606)
QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWTWIRQPPGKGLEWIGEINNSGKTNYNPSLKSRVSISIDTSKNQFSLKVTSVTAADTAVYYCARGPQQHLEPPFDYWGHGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

Light Chain: L
Mutation: NULL

>6XQW_L|Chain B[auth L]|MaliM03 Fab Light Chain|Homo sapiens (9606)
QSVLTQPPSASGTPGQRVTISCSGSNSNIATNYVCWYQQYPGTAPKPLIYRTDQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCATWDDSLSAWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Antigen

Chain: E
Mutation: NULL

>6XQW_E|Chain C[auth E]|Pfmsp1-19|Plasmodium falciparum (5833)
NISQHQCVKKQCPQNSGCFRHLDEREECKCLLNYKQEGDKCVENPNPTCNENNGGCDADAKCTEEDSGSNGKKITCECTKPDSYPLFDGIFCSHHHHHH

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

H: TYR33 GLU50 PRO96 GLN97 GLN98 HIS99

L: THR30 ASN31 TYR32 ARG50 THR51 ASP52 LYS66 TRP91 ASP93 TRP96

E: HIS5 GLN6 CYS7 VAL8 LYS9 LYS10 GLN11 CYS12 GLU24

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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