Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3229 |
| PDBID: | 6XQ4 |
| Chains: | EF_D |
| Organism: | Influenza A virus (A/Beijing/262/1995(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.35 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | S8V2-47 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6XQ4_E|Chain E[auth C], F[auth E]|antibody S8V2-47 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTVSRNYMSWVRQAPGKGLEWVSIIYSGDDTYYADSVKGRFTISRDNSKNTLYLEMNSLRAEDTAVYYCARGEMGDGYYWAPFDYWGQGTLVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: F
Mutation: NULL
| >6XQ4_F|Chain C[auth B], D[auth F]|antibody S8V2-47 light chain|Homo sapiens (9606) DIVMTQSPDSLAVSLGERATINCKSSQSLLYSSRNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRLSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSIPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >6XQ4_D|Chain A, B[auth D]|Hemagglutinin|Influenza A virus (A/Beijing/262/1995(H1N1)) (518922) APLQLGNCSVAGWILGNPECESLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVTASCSHNGKSSFYRNLLWLTEKNGLYPNLSNSYVNNKEKEVLVLWGVHHPSNIRDQRAIYHTENAYVSVVSSHYSRRFTPEIAKRPKVRGQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: GLN27 SER28 LEU30 TYR31 SER32 SER33 ARG34 TYR98 SER99 ILE100 PRO101 E: TYR33 TYR52 SER53 ASP56 THR57 TYR58 ASP99 GLY100 TYR101 TYR102 TRP103 D: THR93 PRO96 GLY97 TYR98 HIS184 ARG211 GLU216 ILE217 ALA218 LYS219 ARG220 PRO221 LYS222 VAL223 GLU227 ARG229 ASN231 TYR233 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
