Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3227 |
| PDBID: | 6XQ2 |
| Chains: | EF_D |
| Organism: | Influenza A virus (A/Texas/50/2012(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | S8V2-37 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6XQ2_E|Chain C[auth B], F[auth E]|antibody S8V2-37 light chain|Homo sapiens (9606) AIQLTQSPSSLSASVGDRVTITCRTSQGISTPLAWYQHKPGKSPKLLIHDAFSLESGVPSRFSGSGSGTDFSLTISSVQPEDFATYYCQQFYDYPITFGQGTRLEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Light Chain: F
Mutation: NULL
| >6XQ2_F|Chain B[auth C], E[auth F]|antibody S8V2-37 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCEASGFTFSNYEMNWVRQAPGKGLEWLSYIRSSGTVTSYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDLVYTGSYYGMDVWGQGTRVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Antigen
Chain: D
Mutation: NULL
| >6XQ2_D|Chain A, D|Hemagglutinin|Influenza A virus (A/Texas/50/2012(H3N2)) (1321009) TNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWNGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPVTDKDQIFLYAQPSGRITVSTKRSQQAVIPNIGFRPRIRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: GLU36 TYR53 ARG55 VAL60 VAL104 THR106 GLY107 SER108 TYR109 E: SER26 GLN27 GLY28 ILE29 SER30 THR31 PRO32 SER65 GLY66 SER67 GLY68 THR69 ASP70 SER72 PHE91 TYR92 ASP93 TYR94 ILE96 D: THR65 SER91 LYS92 ALA93 TYR94 SER95 PRO99 TYR100 ASP101 VAL102 PRO103 TYR105 PHE219 ARG220 PRO221 ARG222 ILE223 ARG224 ASN225 ARG229 ARG269 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
