Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3224 |
| PDBID: | 6XQ0 |
| Chains: | BC_A |
| Organism: | Influenza A virus (A/reassortant/NYMC X-181A(A/NYMC X-157 x California/07/2009)(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | S8V2-18 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6XQ0_B|Chain D[auth B], E|antibody S8V2-18 heavy chain|Homo sapiens (9606) EVQLVESGGGLVRPGGSLTLTCAGSGFMFRSYDMHWVRQAAGKGLEWVAGMGKGGETFYAGSVKGRFTISRENARNSLYLQMHSLRAGDTAVYYCARALTEWLFQRGTRNHYYYGMDVWGQGTTITVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >6XQ0_C|Chain C, F|antibody S8V2-18 light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQIIDNKYLAWYQQKPGQAPRLLIYGASNRATGIPDRFSGSGSGTEFTLIISRLEPEDLAVYYCQQFGSSVYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6XQ0_A|Chain A, B[auth D]|Hemagglutinin|Influenza A virus (A/reassortant/NYMC X-181A(A/NYMC X-157 x California/07/2009)(H1N1)) (1184517) ASAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSDKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKTFKPEIAIRPKVRDREGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR49 THR56 B: MET28 ARG30 SER31 TYR32 LYS53 LEU99 GLU101 TRP102 LEU103 PHE104 GLN105 ARG106 GLY107 THR108 ARG109 TYR114 A: ASN64 ALA66 PRO90 SER91 SER92 ASP93 GLY95 THR96 PRO99 GLY100 ASP101 PHE102 ILE103 ASP104 TYR105 GLU106 ARG109 SER188 ALA198 ASP199 LYS214 PRO215 GLU216 ILE217 ALA218 ILE219 ARG220 PRO221 VAL223 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
