Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3223 |
| PDBID: | 6XPZ |
| Chains: | EF_D |
| Organism: | Influenza A virus (A/Moscow/10/1999(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.45 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | S1V2-83 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6XPZ_E|Chain C[auth B], E|antibody S1V2-83 heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSVRLTCAGSGFSFSNFGMNWVRQAPGKGLEWLAIISYDGSKKWYADSVKGRFTISRDDAKNTLFLQMNSLTAEDTAVYYCSKDRGDVWSGYYRGGDYHYYFGMDVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: F
Mutation: NULL
| >6XPZ_F|Chain D[auth C], F|antibody S1V2-83 light chain|Homo sapiens (9606) DIQMTQSPSSLSTSVGDRVTITCQASQDISNFLNWYQQKPGKAPELLIYDASYLQGGVPSRFSGSGSGTDFSFTISSLQPEDIATYYCQQYNSLPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >6XPZ_D|Chain A, B[auth D]|Hemagglutinin|Influenza A virus (A/Moscow/10/1999(H3N2)) (480019) TNATELVQSSSTGRICDSPHQILDGENCTLIDALLGDPHCDGFQNKEWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVAQNGTSSACKRRSIKSFFSRLNWLHQLENRYPALNVTMPNNDKFDKLYIWGVHHPSTDSVQTSVYVQASGRVTVSTKRSQQTVIPNIGSRPWVRGVSSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQNTLKLATGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: ARG96 ASP98 VAL99 TRP100 SER101 GLY102 TYR103 TYR104 ARG105 GLY106 GLY107 TYR109 PHE113 F: ASN31 PHE32 TYR49 ASP50 TYR53 D: THR65 ASP68 ARG90 ALA93 TYR94 SER95 PRO99 TYR100 ASP101 VAL102 PRO103 TYR105 HIS184 ASN216 SER219 ARG220 PRO221 TRP222 VAL223 ARG224 GLY225 ARG229 SER231 TYR233 ARG269 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
