Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3221 |
| PDBID: | 6XPY |
| Chains: | BC_A |
| Organism: | Influenza A virus (A/Texas/50/2012(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | S1V2-58 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6XPY_B|Chain C[auth B]|Fab heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSLSIYYWSWVRQSPGKGLEWIGYISNSGSPTYHPSLKSRVTISLDTSKSQFSLKLTSVTAADTALYFCARGVLEQLAPDFDSYYYGMNVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >6XPY_C|Chain B[auth C]|Fab light chain|Homo sapiens (9606) DIQMTQSPSSVSASLGDRVTLTCRASQPIRSYLNWYQHKPGLAPKLLVYAVSNLQSGVPSRFSGSGSGTDFTLTVSSLQPEDFATYYCQQSYSTPYTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6XPY_A|Chain A|Hemagglutinin|Influenza A virus (1321009) TNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWNGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPVTDKDQIFLYAQPSGRITVSTKRSQQAVIPNIGFRPRIRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ARG30 LEU46 TYR49 ASN53 LEU54 GLN55 SER56 GLY57 B: GLN1 VAL2 GLY26 GLY27 SER28 SER30 ILE31 TYR32 VAL99 GLU101 GLN102 LEU103 ALA104 PRO105 PHE107 GLY113 ASN115 A: THR65 ILE67 GLU89 ARG90 SER91 ALA93 TYR94 SER95 PRO99 TYR100 ASP101 VAL102 TYR105 ARG109 ASN216 ILE217 GLY218 PHE219 ARG220 PRO221 ARG222 ILE223 ARG224 ASN225 ARG229 ARG269 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
