Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3220 |
| PDBID: | 6XPX |
| Chains: | BC_A |
| Organism: | Influenza A virus (A/Aichi/2/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | S1V2-51 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6XPX_B|Chain C[auth B]|S1V2-51 Fab heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCVASGFTFRDSVMHWVRQAPGKGLEWVAVTSFDGGESYSADSVKGRFTISRDNSKSTLSLQMNILRPEDTGVYYCARDRGGLDVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: C
Mutation: NULL
| >6XPX_C|Chain B[auth C]|S1V2-51 Fab light chain|Homo sapiens (9606) DIVMTQSPESLAVSLGERATINCKSSQSVSFGSSDKNYLGWYQQKPGQPPKLLINWASTRESGVSDRFRGTGSGTDFTLTISSLQAEDAAVYYCHQYYTPPYSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6XPX_A|Chain A|Hemagglutinin|Influenza A virus (387139) TNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTDQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: PHE31 GLY32 SER33 SER34 TYR38 TRP56 TYR97 TYR98 THR99 PRO100 TYR102 B: ASP31 VAL33 VAL50 THR51 SER52 PHE53 ASP54 GLU57 TYR59 ASP99 GLY101 A: SER136 ASN137 ALA138 LYS140 ASN216 ILE217 GLY218 SER219 ARG220 PRO221 TRP222 VAL223 ARG224 GLY225 LEU226 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
