Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3219 |
| PDBID: | 6XPR |
| Chains: | EF_D |
| Organism: | Influenza A virus (A/Texas/50/2012(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.09 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | D2 H1-1/H3-1 H3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6XPR_E|Chain B, E|antibody D2 H1-1/H3-1 H3 heavy chain|Homo sapiens (9606) QVQLVQSGGGLVRPGGSLRLSCAASGFTFSSAWMTWVRQAPGKGLEWVANIKEDGSEKYYVDSVKGRFSISRDNAKNSLYLQISSLRAEDTAVYYCARRFVERLWGQSKPYDAVDIWGQGTMVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: F
Mutation: NULL
| >6XPR_F|Chain C, F|antibody D2 H1-1/H3-1 H3 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSISNYLNWYQQKPGKAPKLLIYVASNLQSGVPSRFSGSGSGTDFALTISSLQPEDFASYYCQQSYSPVTTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >6XPR_D|Chain A, D|Hemagglutinin|Influenza A virus (A/Texas/50/2012(H3N2)) (1321009) TNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWNGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPVTDKDQIFLYAQPSGRITVSTKRSQQAVIPNIGFRPRIRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: PHE27 THR28 SER31 PHE100 GLU102 ARG103 LEU104 TRP105 GLY106 GLN107 ALA113 VAL114 ASP115 F: LEU46 TYR49 VAL50 ASN53 LEU54 GLN55 SER56 D: SER95 PRO99 TYR100 ASP101 VAL102 PRO103 TYR105 ASN216 ILE217 PHE219 ARG220 PRO221 ARG222 ILE223 ARG224 ASN225 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
