Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3217 |
| PDBID: | 6XPQ |
| Chains: | BC_A |
| Organism: | Influenza A virus (A/Texas/50/2012(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.20 |
| Reference: | 10.1128/mBio.01144-21 |
| Antibody | |
| Antibody: | D1 H1-17/H3-14 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6XPQ_B|Chain C[auth B]|antibody D1 H1-17/H3-14 heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSESLSLTCSVSGGSVSSNLHYWSWIRQLPGKGLEWIGYISYTGSTKYNPSLNGRVTLSIDASKNQFSLELSSVTAADTAVYYCARDFFEKLIADDLNAFDIWGQGTMVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSSLEVLFQGPLGHHHHHH |
Light Chain: C
Mutation: NULL
| >6XPQ_C|Chain B[auth C]|antibody D1 H1-17/H3-14 light chain|Homo sapiens (9606) DIRVTQSPSSLSASVGDRVTITCRASQSISRSLNWYQQRPGKAPKFLIYAASNLQSGVPSRFSGGGSGTDFTLTISSLQPEDFATYYCQETYSRTFGQGTKADIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6XPQ_A|Chain A|Hemagglutinin|Influenza A virus (A/Texas/50/2012(H3N2)) (1321009) TNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWNGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPVTDKDQIFLYAQPSGRITVSTKRSQQAVIPNIGFRPRIRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGGALEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ARG31 PHE46 TYR49 ALA50 ASN53 LEU54 GLN55 SER56 SER67 B: VAL2 ASN32 LEU33 ARG99 PHE101 GLU103 LEU105 ILE106 ASP108 LEU110 ALA112 ASP114 ILE115 A: THR65 ILE67 SER91 ALA93 TYR94 TYR100 ASP101 VAL102 TYR105 ARG109 ASN216 PHE219 ARG220 PRO221 ARG222 ILE223 ARG224 ASN225 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
