Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3215 |
| PDBID: | 6XOC |
| Chains: | AB_H |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.45 |
| Reference: | 10.1016/j.celrep.2021.109084 |
| Antibody | |
| Antibody: | anti-idiotype iv4 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | glVRC01 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | P23083; P01857; Q6PYX1; P01859; P01860; P01861; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6XOC_A|Chain A|Iv4 Fab Heavy Chain|Homo sapiens (9606) QVQLQQPGAELVKPGASVKLSCKASAYTFTSYWINWVKQRPGQGLEWIGNIYPGSSSTNYNEKFKTKATLTVDRSSRTAYMQLSSLTSDDSAVYYCARLDSGDWYYYGLDYWGQGTSVTVFNQIKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: B
Mutation: NULL
| >6XOC_B|Chain B|IV4 Fab Light Chain|Homo sapiens (9606) DVLMTQTPLSLPVSLGDQASISCRSSQNIVHYNGNTYLEWYLQKPGQSPKLLIYQVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG |
Antigen
Chain: H
Mutation: NULL
| >6XOC_H|Chain C[auth H]|iGL-VRC01 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGKNCDYNWDFQHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: TYR27 ASN28 GLY29 H: TRP47 GLN61 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
