Complex | |
AACDB_ID: | 3212 |
PDBID: | 6XM2 |
Chains: | DC_J |
Organism: | Homo sapiens |
Method: | XRD |
Resolution (Å): | 1.91 |
Reference: | 10.1126/scitranslmed.abe0407 |
Antibody | |
Antibody: | 4A11.v7 Fab |
Antibody mutation: | No |
INN (Clinical Trial): | |
Antigen | |
Antigen: | Transforming growth factor beta-2 (TGFb2) |
Antigen mutation: | No |
Durg Target: | P61812 |
Antibody
Heavy Chain: D
Mutation: NULL
>6XM2_D|Chain B, D, F, H|4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized|Homo sapiens (9606) EQQLQESGPGLVKPSETLSLTCTVTGFSLSSYTVNWVRQPAGKGLEWIGYISYGGSAYYASWANGRFTISKDSSKNQVSLKLSSVTAADTAVYFCARHMQVGGAPTGSMAAFDPWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: C
Mutation: NULL
>6XM2_C|Chain A, C, E, G|4A11.v7 kappa light chain Fab (VL-CL) humanized|Homo sapiens (9606) EAVLTQSPGTLSLSPGERATLSCQSSQSVYNNNYLSWFQQKPGQPPRLLIYGASTLTSGVPDRFSGSGSGTDFTLTISRLEPEDFAVYYCAGGYSGSSDKYAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: J
Mutation: NULL
>6XM2_J|Chain I, J, K, L|Transforming growth factor beta-2|Homo sapiens (9606) ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
C: TYR30 TYR34 GLY93 TYR94 SER95 GLY96 SER97 LYS100 TYR101 D: THR33 TYR50 SER52 TYR53 GLY54 GLY55 SER56 TYR58 HIS98 GLN100 GLY102 GLY103 GLY107 SER108 J: TYR367 ASN368 THR369 ILE370 ASN371 PRO372 GLU373 ALA374 SER375 ALA376 SER377 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)