Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 321 |
| PDBID: | 2P4A |
| Chains: | B_A |
| Organism: | Bos taurus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.jmb.2007.08.027 |
| Antibody | |
| Antibody: | CAB-RN05 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ribonuclease pancreatic |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >2P4A_B|Chain B, D|ANTIBODY CAB-RN05|Camelus dromedarius (9838) QVQLVESGGGLVQAGGSLRLSCAASGYPWTYIYMGWFRQAPGKEREGVAAMDSGGGGTLYADSVKGRFTISRDKGKNTVYLQMDSLKPEDTATYYCAAGGDALVATRYGRWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >2P4A_A|Chain A, C|Ribonuclease pancreatic|Bos taurus (9913) KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLN1 TYR27 TRP29 THR30 TYR31 ILE32 TYR33 GLY99 GLY100 ASP101 THR106 ARG107 TYR108 GLY109 ARG110 A: SER59 GLN60 LYS61 ASN62 VAL63 ALA64 GLN69 THR70 ASN71 TYR73 TYR76 GLU111 GLY112 TYR115 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
