Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3206 |
| PDBID: | 6XKR |
| Chains: | HL_P |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.59 |
| Reference: | 10.1158/1535-7163.MCT-20-0093 |
| Antibody | |
| Antibody: | Sasanlimab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Sasanlimab(Phase-III) |
| Antigen | |
| Antigen: | Programmed cell death protein 1(PD-1) |
| Antigen mutation: | No |
| Durg Target: | Q15116 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6XKR_H|Chain A[auth H]|Sasanlimab Fab Heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWINWVRQAPGQGLEWMGNIYPGSSLTNYNEKFKNRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARLSTGTFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCAAAHHHHHHHH |
Light Chain: L
Mutation: NULL
| >6XKR_L|Chain B[auth L]|Sasanlimab Fab Light chain|Homo sapiens (9606) DIVMTQSPDSLAVSLGERATINCKSSQSLWDSGNQKNFLTWYQQKPGQPPKLLIYWTSYRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYFYPHTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: P
Mutation: NULL
| >6XKR_P|Chain C[auth P]|Programmed cell death protein 1|Homo sapiens (9606) WNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPGSGSHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: GLN1 VAL2 THR28 SER31 TYR32 TRP33 TYR52 SER55 LEU57 SER100 THR101 GLY102 THR103 PHE104 TYR106 L: GLY33 ASN34 LYS36 PHE38 TYR55 TRP56 SER58 TYR59 ARG60 GLU61 SER62 GLY63 VAL64 SER69 GLY70 P: SER62 VAL64 ASN66 TYR68 SER71 SER73 ASN74 GLN75 THR76 ASP77 LYS78 ASP85 SER87 GLN88 PRO89 GLY90 LEU122 ILE126 LEU128 ALA129 PRO130 ALA132 GLN133 ILE134 LYS135 GLU136 ARG139 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
