Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 32 |
| PDBID: | 1FBI |
| Chains: | QP_Y |
| Organism: | Mus musculus, Numida meleagris |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1074/jbc.270.30.18067 |
| Antibody | |
| Antibody: | F9.13.7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | GUINEA FOWL Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: Q
Mutation: NULL
| >1FBI_Q|Chain B[auth H], E[auth Q]|IGG1 F9.13.7 FAB (HEAVY CHAIN)|Mus musculus (10090) QVQLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQGPGQGLEWIGEIDPSDSYPNYNEKFKGKATLTVDKSSSTAYMQLSSLTSEDSAVYYCASLYYYGTSYGVLDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVP |
Light Chain: P
Mutation: NULL
| >1FBI_P|Chain A[auth L], D[auth P]|IGG1 F9.13.7 FAB (LIGHT CHAIN)|Mus musculus (10090) DIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQKKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTIRNLEQEDIATYFCQQGYTLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: Y
Mutation: NULL
| >1FBI_Y|Chain C[auth X], F[auth Y]|GUINEA FOWL LYSOZYME|Numida meleagris (8996) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNSQATNRNTDGSTDYGVLQINSRWWCNDGRTPGSRNLCNIPCSALQSSDITATANCAKKIVSDGNGMNAWVAWRKHCKGTDVRVWIKGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| P: SER30 TYR32 GLY91 TYR92 THR93 LEU94 TYR96 Q: THR30 SER31 TYR32 TRP33 GLU50 ASP52 SER54 ASP55 TYR57 ASN59 TYR60 TYR100 TYR101 TYR102 GLY103 THR104 SER105 Y: ARG14 HIS15 GLY16 ASN19 TYR20 ARG21 ARG61 TRP62 TRP63 GLY71 SER72 ARG73 ASN74 LEU75 CYS76 ASN77 ILE78 THR89 ALA90 ASN93 LYS96 LYS97 SER100 ASP101 GLY102 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
