Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3191 |
| PDBID: | 6XCJ |
| Chains: | HL_G |
| Organism: | Human immunodeficiency virus 1, Macaca mulatta |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1126/science.abd2638 |
| Antibody | |
| Antibody: | DH650 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6XCJ_H|Chain B[auth H]|DH650 Fab Heavy Chain|Macaca mulatta (9544) QVQLVQSGAEVKKPGASVKLSCKASGYGFTIYSINWVRQAPGQGLEWMGWINPRNGRIGYAQKFQDRVTMTRDTSTSIAYMELGSLRYEDTAVYFCTRGQLELTASRFDKWGQGVPVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >6XCJ_L|Chain C[auth L]|DH650 Fab Light Chain|Macaca mulatta (9544) DIVMTQSPLSLPVTPGEPAAISCRSSQSLLDRADGNTYLDWYLQKPGQSPQLLIYEVSNRASGVPDRFSGSGSDTDFTLKISRVEAEDVGVYYCMQGLEFPYSFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >6XCJ_G|Chain A[auth G]|Envelope Glycoprotein gp120|Human immunodeficiency virus 1 (11676) VWKEAKTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLKNVTENFNMWKNDMVDQMHEDVISLWDQSLKPCVKLTGGSVITQACPKVSFDPIPIHYCAPAGYAILKCNNKTFTGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEGEIIIRSENITNNVKTIIVHLNESVKIECTRPGNGGSGSGGDIREAYCNINESKWNETLQRVSKKLKEYFPHKNITFQPSSGGDLEITTHSFNCGGEFFYCNTSSLFNRTYMANSTDMANSTETNSTRTITIHCRIKQIINMWQEVGRAMYAPPIAGNITCISIITGLLLTRDGGKNNTETFRPGGGNMKDNWRSELYKYKVVEVK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TRP50 ARG54 ASN55 GLY56 ARG57 ILE58 TYR60 GLN62 GLN65 ARG72 GLU102 LEU103 THR104 ALA105 L: GLN27 LEU30 ASP31 ARG32 ALA33 ASP34 GLY35 ASN36 TYR38 GLY97 LEU98 GLU99 PHE100 TYR102 G: ASN94 TRP96 LYS97 THR236 SER274 GLU275 ASN276 THR278 ASN279 ASN280 VAL281 LYS282 THR283 PHE353 SER364 GLY365 GLY366 ASP367 ILE370 THR454 ARG455 ASP456 GLY457 GLY458 LYS459 ARG466 GLY469 GLY470 ASN471 LYS473 ARG477 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
