Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3174 |
| PDBID: | 6X06 |
| Chains: | K_A |
| Organism: | Saccharomyces cerevisiae S288C, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 4.27 |
| Reference: | 10.1038/s41467-020-19884-6 |
| Antibody | |
| Antibody: | SAN11 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Nucleoporin NUP120(aa1-757) from S. cerevisiae |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: K
Mutation: NULL
| >6X06_K|Chain B[auth K]|VHH-SAN11|Vicugna pacos (30538) QVQLVETGGGLVRAGGSLRLSCVDSGRTFRVYTMGWFRQAPGKEREFVAAIRWSGDRTYYGDPVQGRFTISRDKGKNTVYLQMNSLKPEDTAVYYCAAPAGGGVVYDDHKAYAYWGQGTQVTVS |
Antigen
Chain: A
Mutation: NULL
| >6X06_A|Chain A|Nucleoporin NUP120|Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (559292) SMACLSRIDANLLQYYEKPEPNNTVDLYVSNNSNNNGLKEGDKSISTPVPQPYGSEYSNCLLLSNSEYICYHFSSRSTLLTFYPLSDAYHGKTINIHLPNASMNQRYTLTIQEVEQQLLVNVILKDGSFLTLQLPLSFLFSSANTLNGEWFHLQNPYDFTVRVPHFLFYVSPQFSVVFLEDGGLLGLKKVDGVHYEPLLFNDNSYLKSLTRFFSRSSKSDYDSVISCKLFHERYLIVLTQNCHLKIWDLTSFTLIQDYDMVSQSDSDPSHFRKVEAVGEYLSLYNNTLVTLLPLENGLFQMGTLLVDSSGILTYTFQNNIPTNLSASAIWSIVDLVLTRPLELNVEASYLNLIVLWKSGTASKLQILNVNDESFKNYEWIESVNKSLVDLQSEHDLDIVTKTGDVERGFCNLKSRYGTQIFERAQQILSENKIIMAHNEDEEYLANLETILRDVKTAFNEASSITLYGDEIILVNCFQPYNHSLYKLNTTVENWFYNMHSETDGSELFKYLRTLNGFASTLSNDVLRSISKKFLDIITGELPDSMTTVEKFTDIFKNCLENQFEITNLKILFDELNSFDIPVVLNDLINNQMKPGIFWKKDFISAIKFDGFTSIISLESLHQLLSIHYRITLQVLLTFVLFDLDTEIFGQHISTLLDLHYKQFLLLNLYRQDKCLLAEVLLKDSSEFSFGVKFFNYGQLIAYIDSLNSNVYNASITENSFFMTFFRSYIIENTSHKNIRFFLENVECPFYLRHNEVQE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition K: PHE29 ARG30 VAL31 TYR32 ARG52 TRP53 TYR59 PRO99 GLY101 GLY102 GLY103 VAL104 VAL105 TYR106 A: SER428 LYS431 ILE432 ILE433 MET434 ALA435 HIS436 ASN437 GLU438 ASP439 GLU440 GLU441 TYR442 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
