Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3162 |
| PDBID: | 6WTY |
| Chains: | BC_A |
| Organism: | Plasmodium vivax Sal-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.48 |
| Reference: | 10.1038/s41467-021-21811-2 |
| Antibody | |
| Antibody: | 253245 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6WTY_B|Chain E[auth B], G[auth E], J[auth H], K|253245 Fab heavy chain|Homo sapiens (9606) TGVHSEVQLVQSGAEVKKPGSSMKVSCKASGGTFNRYVFSWVRQAPGQGLEWMGGILPILETTYYAKNFKGRVTITADESTSTVYMELSSLTSEDTAVYFCARDEHDYVWGSYRPSLTGPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: C
Mutation: NULL
| >6WTY_C|Chain D[auth C], F, H[auth I], L|253245 Fab light chain|Homo sapiens (9606) TGSWAQSALTQPPSTSGSPGQSVTISCTGTGIDVGGFSYVSWFQYHPGKAPKLIIFEVTKRPSGVPDRFSGSKSGNTASLTISGLQADDEAEYYCSSYAVNNNFVFGTGTKVTVLVSPRPTPLSLCSHPRSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6WTY_A|Chain A, B[auth D], C[auth G], I[auth J]|reticulocyte binding protein 2b|Plasmodium vivax (strain Salvador I) (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: THR30 GLY31 ILE32 GLY35 GLY36 PHE37 SER38 TYR39 THR59 LYS73 SER74 GLY75 TYR98 VAL100 ASN101 ASN102 B: ARG36 ILE59 LEU60 THR62 TYR108 VAL109 TRP110 GLY111 SER112 ARG114 A: SER184 ASN185 TYR186 ASP341 ILE344 LYS345 LYS348 ASN349 TYR351 LEU352 VAL355 ASP356 LYS379 GLY382 ILE385 ASP386 ARG387 GLU389 TYR390 LEU392 GLN393 LYS394 LYS396 HIS397 ASP400 GLN401 ALA404 TYR422 ASN425 ASN428 TYR429 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
