Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3160 |
| PDBID: | 6WTV |
| Chains: | HI_G |
| Organism: | Plasmodium vivax Sal-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.05 |
| Reference: | 10.1038/s41467-021-21811-2 |
| Antibody | |
| Antibody: | 258259 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6WTV_H|Chain C[auth B], E, H, J[auth K]|258259 Fab heavy chain|Homo sapiens (9606) TGVHSEVQLLESGGGLVRPGGSQRLSCAASGFTFTPYAMTWVRQAPGKGLEWLSTISGSGGSTYYADSVKGRFTISRDNSKNMLYLQMNSLTAEDTALYYCTKDKDEYTFGHNAFDVWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: I
Mutation: NULL
| >6WTV_I|Chain B[auth C], F, I, K[auth L]|258259 Fab light chain|Homo sapiens (9606) TGSVTSYELTQAPSVSVAPGQTARITCGGDNIGRKTVNWYQQKPGQAPVLVIYYDNDRPSGIPERFSGSNSGNMATLSISRVEVGDEADYYCQVWDSNNDHPVFGGGTKLTVVGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: G
Mutation: NULL
| >6WTV_G|Chain A, D, G, L[auth J]|reticulocyte binding protein 2b|Plasmodium vivax (strain Salvador I) (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR35 SER57 GLY58 SER59 GLY60 GLY61 SER62 TYR64 ASN79 SER80 ASP106 GLU107 TYR108 THR109 PHE110 HIS112 ASN113 I: GLY33 ARG34 LYS35 THR36 TYR54 ASP55 ASN56 ASP57 ASN70 TRP95 G: GLU183 SER184 ASN185 LYS278 ARG282 LYS348 TYR351 LEU352 VAL355 ASP356 ARG359 LYS360 GLU362 LYS363 LYS379 GLY382 TYR383 ILE385 ASP386 ARG387 GLU389 TYR390 GLN393 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
