Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3156 |
| PDBID: | 6WTU |
| Chains: | HI_G |
| Organism: | Plasmodium vivax Sal-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.55 |
| Reference: | 10.1038/s41467-021-21811-2 |
| Antibody | |
| Antibody: | 273264 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6WTU_H|Chain B, D[auth E], E[auth H], G[auth K]|273264 Fab heavy chain|Homo sapiens (9606) TGVHSEVQLLESGGGLVRPGGSQRLSCAASGFTFTPYAMTWVRQAPGKGLEWLSTISGSGGSTSYADSVKGRFTISRDNSKNILYLQMDSLRAEDTALYYCTKDKDEYTFGHNAFDVWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: I
Mutation: NULL
| >6WTU_I|Chain C, F, I, J[auth L]|273264 Fab light chain|Homo sapiens (9606) TGSVTSYELTQAPSVSVAPGQTARITCGGDNIGRTSVHWYQQKPGQAPVLVIFYDNDRPSGIPERFSGSNSGNMATLSISRVEVGDEADYYCQVWDSNNDHPVFGGGTKLTVVGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: G
Mutation: NULL
| >6WTU_G|Chain A, H[auth D], K[auth G], L[auth J]|reticulocyte binding protein 2b|Plasmodium vivax (strain Salvador I) (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: GLY33 ARG34 THR35 SER36 HIS38 TYR54 ASP55 ASN56 ASP57 ASN70 TRP95 SER97 ASP100 H: THR35 SER57 GLY58 SER59 GLY60 GLY61 SER62 ASN79 SER80 GLU107 TYR108 THR109 PHE110 HIS112 ASN113 G: GLU183 SER184 ASN185 GLU275 LYS278 LYS348 ASN349 TYR351 LEU352 SER353 VAL355 ASP356 ARG359 LYS360 GLU362 LYS363 LYS379 GLY382 TYR383 ILE385 ASP386 ARG387 GLU389 TYR390 GLN393 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
