Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3152 |
| PDBID: | 6WQO |
| Chains: | BC_A |
| Organism: | Plasmodium vivax Sal-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.15 |
| Reference: | 10.1038/s41467-021-21811-2 |
| Antibody | |
| Antibody: | 283284 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6WQO_B|Chain C[auth B], E|283284 Fab heavy chain|Homo sapiens (9606) TGVHSQVQLQQWGAGLLKPSETLALTCTVYGGSSSGYYWNWIRQSPGKGLEWIGEISDSGSTIYNPSLESRVTMSVDTSKNQFSLKLTSVTAADTAVYYCAKAILTRYNWLDPWSQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: C
Mutation: NULL
| >6WQO_C|Chain D[auth C], F|283284 Fab light chain|Homo sapiens (9606) TGVHSDIVMTQSPSSLSASVGDRISISCRASQGVNSALAWYQQKPGKAPKLLIYDASTLESGVPSRFSGSGSGTDFALTINSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6WQO_A|Chain A, B[auth D]|reticulocyte binding protein 2b|Plasmodium vivax (strain Salvador I) (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLN6 VAL7 GLY31 GLY32 SER33 SER35 GLY36 TYR37 ASP58 SER59 THR78 LYS102 ILE104 LEU105 TYR108 TRP110 ASP112 C: SER36 TYR54 ASP55 SER57 THR58 GLU60 SER61 A: ARG207 SER210 TYR211 HIS212 THR213 LYS216 GLN317 ASN319 VAL320 ASP323 MET324 LYS326 ILE327 VAL330 ASP331 LYS333 LYS334 LYS410 LYS412 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
