Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3144 |
| PDBID: | 6WOZ |
| Chains: | EF_D |
| Organism: | Plasmodium vivax Sal-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41467-021-21811-2 |
| Antibody | |
| Antibody: | 251249 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6WOZ_E|Chain B, D[auth E], H, J[auth K]|251249 Fab heavy chain|Homo sapiens (9606) TGVHSEVQLVESGGGLVKPGGSLRLSCEASGFLFSSYSMNWVRQAPGKGLEWVSSITGYSSEVFYTDSVKGRFTVSRDNSKNSLYLQMDSLRAEDTAVYYCARALTIFGVVITDYWFFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: F
Mutation: NULL
| >6WOZ_F|Chain C, E[auth F], I, K[auth L]|251249 Fab light chain|Homo sapiens (9606) TGVHSEIVLTQSPATLSLSPGDRATLSCRASQSVTTFLAWYQQKPGQAPRLLIYDVSNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWGLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >6WOZ_D|Chain A, F[auth D], G, L[auth J]|reticulocyte binding protein 2b|Plasmodium vivax (strain Salvador I) (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: LEU33 SER35 SER36 SER38 THR57 GLY58 TYR59 SER60 SER61 GLU62 THR106 PHE108 GLY109 VAL110 VAL111 ILE112 THR113 ASP114 TYR115 F: THR35 THR36 PHE37 ASP55 ASN58 ARG96 D: ASP182 GLU183 SER184 TYR186 TYR187 ASN198 PHE201 ARG290 LYS291 LEU293 ASP294 GLN295 LYS297 LYS298 ASN300 ASN301 ARG304 ASP305 GLU308 ASN417 GLU421 PHE424 ASN425 ASN428 TYR429 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
