Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3137 |
| PDBID: | 6WO3 |
| Chains: | HL_E |
| Organism: | Recombinant Hepatitis C virus HK6a/JFH-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.38 |
| Reference: | 10.1126/sciadv.abb5642 |
| Antibody | |
| Antibody: | U1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C Virus Envelope Glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6WO3_H|Chain B[auth H]|Fab U1 heavy chain|Homo sapiens (9606) EVQLLEQSGPEVKRPGTSVKMSCKISGGASITQAMSWVRQAPGQGLEWMGGITPIFGTVNYAQKILGRVTITADEDTVSLELSSLKSEDTAVYYCAREVNLKTWNLAHPNVFDVWGQGTMLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCGS |
Light Chain: L
Mutation: NULL
| >6WO3_L|Chain C[auth L]|Fab U1 light chain|Homo sapiens (9606) LTLTQSPSSLSASVGDRVTITCRASQSISSFLNWYQQKPGKAPKLLIYAASSLQSGVPPRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6WO3_E|Chain A[auth E]|Envelope glycoprotein E2|Recombinant Hepatitis C virus HK6a/JFH-1 (595609) QLINTNGSWHINRTALNCNDSLQTGFITSLFYAKNVDSSGCPERMAACGSSGCWHYAPRPCDVVSARTVCGPVYCFTPSPVVVGTTDKLGIPTYNWGENETDVFMLESLRPPTGGWFGCTWMNSTGFTKTCGAPPGGPTDGGSGPWITPRCLVDYPYRLWHYPCTVNFTLHKVRMFVGGIEHRFDAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN2 ALA28 SER29 ILE30 THR31 GLN32 PRO52 ILE53 PHE54 ASP72 GLU73 ARG94 ASN97 E: ASN423 LEU427 ASN428 CYS429 ASN430 ASP431 SER432 GLN434 ILE438 THR439 PHE442 TYR443 ARG500 ASN528 TRP529 GLU531 SER557 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
