Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3134 |
| PDBID: | 6WN1 |
| Chains: | EF_D |
| Organism: | Plasmodium vivax Sal-1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.15 |
| Reference: | 10.1038/s41467-021-21811-2 |
| Antibody | |
| Antibody: | 241242 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium vivax reticulocyte binding protein 2b (PvRBP2b) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6WN1_E|Chain B, F[auth E]|241242 Fab heavy chain|Homo sapiens (9606) TGVHSEVQLLESGGGLVQPGGSLRLSCAVSGFTFRNYALSWVRQAPGKGLDWVSTISASGGATYYADSVKGHFTISRDNSKNILYLDMKSLRAEDTAIYYCARDGGSYTPYFFLDSWGQGALVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP |
Light Chain: F
Mutation: NULL
| >6WN1_F|Chain C, D[auth F]|241242 Fab light chain|Homo sapiens (9606) TGSVTSYELTQPASVSVAPGQTAQITCGGNSIGRKSIHWYQHKPGQAPVLVISYDSDRPSGIPERFSGSNSGNTATLTISKVEAGDEADFYCQVRDSDNDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >6WN1_D|Chain A, E[auth D]|Reticulocyte binding protein 2b|Plasmodium vivax Sal-1 (126793) GAMGSTNTTDNIDYFDISDESNYYLISQLRPHFSNIYFFDEFKRYASYHTEIKRYEDIHKTKVNSLLNEASRAIGICNRAKNTVKGLINILENPQKFKTQRESYDVKLRQYEEKKEAFRGCLLNKNRKNLDQIKKINNEIRDLLEKLKCSQDCQTNVYFDMIKIYLVDFKKMPYENYDTFIKQYKNSYLSGVDMIRKIEKQIDNPVTINAIKFTQKEMGYIIDRFEYHLQKVKHSIDQVTALSDGVKPKQVTKNRLKEYYFNIGNYYSIFKFGKDSLNMLNKALIHKEKIVHNLLGELFGHLEERIS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition F: GLY33 ARG34 LYS35 SER36 TYR54 ASP55 SER56 ASP57 ASN70 ARG95 SER97 E: ARG35 ASN36 SER57 ALA58 SER59 GLY60 GLY61 ALA62 TYR64 ASP78 ASN79 SER80 SER107 TYR108 THR109 PRO110 TYR111 PHE112 D: ILE180 SER181 ASP182 GLU183 SER184 ASN185 LYS278 GLU279 ARG282 LYS348 ASN349 TYR351 LEU352 SER353 VAL355 ASP356 ARG359 LYS360 GLU362 LYS363 GLN378 LYS379 GLY382 TYR383 ILE385 ASP386 ARG387 GLU389 TYR390 GLN393 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
