Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3120 |
| PDBID: | 6WHK |
| Chains: | CB_A |
| Organism: | Influenza A virus (A/Beijing/262/1995(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 6WHK Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6WHK_C|Chain B[auth C]|Fab Heavy Chain|Homo sapiens (9606) ASEVQLVESGGGLVQPGRSLRLSCTASGFTFGDYGMSWFRQAPGKGLEWVGFIRSKVYGGTTEYAASVKGRFIISRDDSKSIAYLQMNSLKTEDTAVYYCTRDWVRDIILLPALHLDYWGQGTLVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH |
Light Chain: B
Mutation: NULL
| >6WHK_B|Chain C[auth B]|Fab Light Chain|Homo sapiens (9606) ASQSVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWFQQLPGTAPKLLIYDDDKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSRLSAGVVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6WHK_A|Chain A|Hemagglutinin HA1 chain|Influenza A virus (A/Beijing/262/1995(H1N1)) (518922) ASLKGIAPLQLGNCSVAGWILGNPECESLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVTASCSHNGKSSFYRNLLWLTEKNGLYPNLSNSYVNNKEKEVLVLWGVHHPSNIRDQRAIYHTENAYVSVVSSHYSRRFTPEIAKRPKVRGQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGGSLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: LYS54 VAL55 TYR56 GLY57 ARG104 ASP105 ILE106 ILE107 LEU108 LEU109 B: SER26 SER27 GLY30 ASN31 ASN32 TYR33 ASP51 ASP52 ASP53 SER66 LYS67 SER94 ARG95 LEU96 A: TYR95 THR133 GLY134 VAL135 THR136 ALA137 SER140 GLY143 LYS144 SER145 TRP153 THR155 GLU156 ASN158 GLY159 HIS183 ASN187 ARG189 ASP190 ARG192 ALA193 ILE194 HIS196 GLN226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
