Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3115 |
| PDBID: | 6WER |
| Chains: | EF_B |
| Organism: | dengue virus type 2, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.96 |
| Reference: | 10.1126/science.abc0476 |
| Antibody | |
| Antibody: | 2B7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | DENV2 Non-structural protein 1 |
| Antigen mutation: | No |
| Durg Target: | P12823; P27914; |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6WER_E|Chain C, E|2B7 Fab heavy chain|Mus musculus (10090) MEWSWIFLFLLSGTAGVHSEVQLQQSGPELVKPGASVKMSCKASGCTLTNCFMHWMKQKPGQDLEWIGYINPYNDMTKYSENFKGKATLTSDKSSSTAFMELSSLTSEDSAVYYCARGYLLRTGCFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSV |
Light Chain: F
Mutation: NULL
| >6WER_F|Chain D, F|2B7 Fab light chain|Mus musculus (10090) METDTLLLWVLLLWVPGSTGNIVLTQSPASLAVSLGQRATISCRASESVDSYGYSFMHWYQQKPGQPPKVLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNENPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: B
Mutation: NULL
| >6WER_B|Chain A, B|Non-structural protein 1|Dengue virus 2 (11060) AHHHHHHSSGVDLGTENLYFQSNADSGCVVSWKNKELKCGSGIFITDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQPTELKYSWKTWGKAKMLSTESHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLKLKEKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKNCHWPKSHTLWSNGVLESEMIIPKNLAGPVSQHNYRPGYHTQITGPWHLGKLEMDFDFCDGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: THR28 LEU29 THR30 ASN31 TYR50 ASN54 MET56 LYS58 TYR99 LEU100 LEU101 ARG102 THR103 GLY104 CYS105 ASP107 F: TYR32 TYR34 PHE36 TYR53 LEU54 ASN98 B: HIS269 LEU270 ASP281 GLY282 ARG299 THR300 THR301 ALA303 SER304 GLY305 LYS306 LEU307 GLY325 GLU326 ASP327 GLY328 CYS329 TRP330 GLU343 ASN344 LEU345 VAL346 ASN347 LEU349 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
