Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3112 |
| PDBID: | 6WEQ |
| Chains: | GH_B |
| Organism: | dengue virus type 1, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1126/science.abc0476 |
| Antibody | |
| Antibody: | 2B7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | DENV2 Non-structural protein 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >6WEQ_G|Chain E, G, I, K|2B7 Fab fragment heavy chain|Mus musculus (10090) MEWSWIFLFLLSGTAGVHSEVQLQQSGPELVKPGASVKMSCKASGCTLTNCFMHWMKQKPGQDLEWIGYINPYNDMTKYSENFKGKATLTSDKSSSTAFMELSSLTSEDSAVYYCARGYLLRTGCFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTINPCPPCKECHKCPAPNLEGGPSV |
Light Chain: H
Mutation: NULL
| >6WEQ_H|Chain F, H, J, L|2B7 Fab fragment light chain|Mus musculus (10090) METDTLLLWVLLLWVPGSTGNIVLTQSPASLAVSLGQRATISCRASESVDSYGYSFMHWYQQKPGQPPKVLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNENPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: B
Mutation: NULL
| >6WEQ_B|Chain A, B, C, D|Non-structural protein 1|Dengue virus 1 (11053) AHHHHHHSSGVDLGTENLYFQSNADSGCVINWKGRELKCGSGIFVTNEVHTWTEQYKFQADSPKRLSAAIGKAWEEGVCGIRSATRLENIMWKQISNELNHILLENDMKFTVVVGDVSGILAQGKKMIRPQPMEHKYSWKSWGKAKIIGADVQNTTFIIDGPNTPECPDNQRAWNIWEVEDYGFGIFTTNIWLKLRDSYTQVCDHRLMSAAIKDSKAVHADMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDFCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGMEIRPVKDKEENLVKSMVSA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: LEU29 THR30 ASN31 TYR50 ASN54 MET56 LYS58 TYR99 LEU100 LEU101 ARG102 THR103 GLY104 H: ASN1 GLU27 TYR32 GLY33 TYR34 PHE36 TYR53 LEU54 GLU97 ASN98 B: ASP92 SER94 PRO138 HIS269 LEU270 GLU281 GLY282 ARG299 THR301 THR302 VAL303 THR304 GLY305 ILE307 LYS324 GLU326 ASP327 GLY328 TRP330 ASN344 LEU345 VAL346 LYS347 SER348 MET349 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
