Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 310 |
| PDBID: | 2OZ4 |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1073/pnas.0707406104 |
| Antibody | |
| Antibody: | CA7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Intercellular adhesion molecule 1 |
| Antigen mutation: | No |
| Durg Target: | P05362 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2OZ4_H|Chain C[auth H]|FAB FRAGMENT, HEAVY CHAIN|Mus musculus (10090) EVQLQQSGPELVQPGASVKISCKTSGYTFSEFTMHWVKQSHGKSLEWIGGINTINGGSSYKQSFKDKATLTVDKSSSTAYMELNSLTSEDSAVYYCATKGFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >2OZ4_L|Chain B[auth L]|FAB FRAGMENT LIGHT CHAIN|Mus musculus (10090) DILLTQSPAILSVSPGERVSFSCRASQSIGTSIHWFQQRINGSPRLLIEYASESISGIPSRFSGSGSGTDFTLTINSVESEDIADYYCQQSNVWPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >2OZ4_A|Chain A|Intercellular adhesion molecule 1|Homo sapiens (9606) VLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTREVTVNVLSP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER32 HIS34 LEU46 GLU49 TYR50 SER56 SER91 ASN92 VAL93 TRP94 PHE96 H: GLU1 THR28 SER30 GLU31 PHE32 THR33 HIS35 GLY50 ASN52 THR53 ILE54 ASN55 GLY57 SER58 SER59 LYS65 LYS99 GLY100 PHE101 ALA102 TYR103 A: PRO335 GLU336 ASN338 GLY339 SER341 TYR367 ASP372 GLU373 ARG374 ASP375 PRO377 GLY378 ASN379 TRP380 THR381 GLN387 THR389 MET391 CYS392 GLN393 ALA394 TRP395 GLY396 LEU399 PRO400 ILE414 GLY415 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
