Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3064 |
| PDBID: | 6VY5 |
| Chains: | HL_A |
| Organism: | Homo sapiens, Henipavirus nipahense |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1016/j.cell.2020.11.023 |
| Antibody | |
| Antibody: | HENV-26 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Nipah (NiV) viruses receptor binding protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6VY5_H|Chain A[auth H]|Anti-Hendra receptor binding protein antibody HENV-26 Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLIQPGGSLRLSCAASGFTFSRFTMSWVRQPPGKGPEWVSGISGSGGHTYYADSVKGRFTISRDNSKNTLYLQMNSLKAEDTAVYYCAKDGFVGQQLMRRGPWWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >6VY5_L|Chain B[auth L]|Anti-Hendra receptor binding protein antibody HENV-26 Fab light chain|Homo sapiens (9606) SYVLTQPPSVSVAPGQTARISCGGNNIGNKGVHWYQQKPGQAPVVVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6VY5_A|Chain C[auth A]|receptor binding protein|Nipah henipavirus (3052225) GLPNNICLQKTSNQILKPKLISYTLPVVGQSGTCITDPLLAMDEGYFAYSHLERIGSCSRGVSKQRIIGVGEVLDRGDEVPSLFMTNVWTPPNPNTVYHCSAVYNNEFYYVLCAVSTVGDPILNSTYWSGSLMMTRLAVKPKSNGGGYNQHQLALRSIEKGRYDKVMPYGPSGIKQGDTLYFPAVGFLVRTEFKYNDSNCPITKCQYSKPENCRLSMGIRPNSHYILRSGLLKYNLSDGENPKVVFIEISDQRLSIGSPSKIYDSLGQPVFYQASFSWDTMIKFGDVLTVNPLVVNWRNNTVISRPGQSQCPRFNTCPEICWEGVYNDAFLIDRINWISAGVFLDSNQTAENPVFTVFKDNEILYRAQLASEDTNAQKTITNCFLLKNKIWCISLVEIYDTGDNVIRPKLFAVKIPEQCTENLYFQGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ARG31 PHE32 THR33 SER52 GLY53 SER54 GLY55 GLY56 HIS57 TYR59 ASP99 PHE101 GLN104 GLN105 LEU106 MET107 ARG108 ARG109 PRO111 TRP112 L: TYR3 ASN26 ASN27 GLY29 ASN30 LYS31 ASN66 SER67 GLY68 TRP91 SER93 SER94 ASP96 A: LEU305 TYR389 ASN394 ILE401 ARG402 PRO403 ASN404 PHE458 PRO488 GLY489 GLN490 SER491 GLN492 PRO494 ASN497 GLU501 ILE502 TRP504 GLU505 GLY506 VAL507 SER528 ASN529 GLN530 THR531 ALA532 GLU533 GLU554 ASP555 THR556 ASN557 TYR581 THR583 ASN586 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
