Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 3063 |
| PDBID: | 6VY4 |
| Chains: | CD_B |
| Organism: | Henipavirus hendraense, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1016/j.cell.2020.11.023 |
| Antibody | |
| Antibody: | HENV-32 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hendra (HeV) viruses receptor binding protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6VY4_C|Chain C, E[auth H]|Anti-Hendra receptor binding protein antibody HENV-32 Fab heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKVSGGIFNRETINWVRQAPGQGLEWMGRITPIVDVPNYPRKFRGRVTITADKSTSTVYMELSGLRFEDTAIYFCARFRGHNYFDPWGQGTLVTVSSASFKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: D
Mutation: NULL
| >6VY4_D|Chain D, F[auth L]|Anti-Hendra receptor binding protein antibody HENV-32 Fab light chain|Homo sapiens (9606) SYVLTQPPSVSVAPGQTARITCGGNNIGGKSVHWYQQKPGQAPVLVVYDDRDRPSGIPERFSGSNSGDTASLTISRVDAGDEADYFCQVWDNASDEAVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >6VY4_B|Chain A, B|receptor binding protein|Hendra henipavirus (3052223) PNQICLQKTTSTILKPRLISYTLPINTREGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIHHCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMPYGPSGIKQGDTLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSLGGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQSQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQKTITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQCSESENLYFQGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ILE28 ARG31 GLU32 THR33 ARG50 THR52 ILE54 VAL55 VAL57 ARG62 ARG65 ARG98 PHE99 ARG100 GLY101 HIS102 ASN103 TYR104 D: GLY29 GLY30 LYS31 SER32 TYR49 ASP50 ASP51 ASN66 TRP91 ASN93 ALA94 SER95 ASP96 B: THR196 LEU198 LYS199 PRO200 ARG201 LEU202 ILE203 TYR205 THR206 LEU207 PRO208 ASN210 GLU254 LEU256 ARG258 GLY259 ASP260 LYS261 VAL262 PRO263 SER264 PHE266 MET267 THR268 LEU551 GLU553 ASP582 THR583 GLY584 ASP585 LYS591 PHE593 ALA594 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
